HRM Introduction
High Resolution
Melting (HRM) is
a novel,
homogeneous, close-tube, post-PCR
method, enabling genomic researchers to analyze genetic variations
(SNPs, mutations, methylations) in PCR amplicons. It goes beyond the
power of classical melting curve analysis by allowing to study the
thermal denaturation of a double-stranded DNA in much more detail and
with much higher information yield than ever before.
HRM
characterizes nucleic acid samples based on their disassociation
(melting) behavior. Samples can be discriminated according to their
sequence, length, GC content or strand complementarity. Even single
base changes such as SNPs (single nucleotide polymorphisms) can be
readily identified.
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